Chloroquine – a potential treatment for coronavirus

Chloroquine is a new and highly efficient medication intended for the treatment of cytomegalovirus, hepatitis viruses, and herpes virus that don’t respond to standard treatment or have a complicated course in conjunction with accompanying pathology.

Once inside the cell, the active component binds to DNA polymerase of the virus, suppressing it, which impedes further protein synthesis and viral DNA transcription. Consequently, virus reproduction ends.

The medication is excreted by kidneys unaltered. The half-life of Chloroquine is 1-8 hours. It will be fully eliminated from the body within about 4 days. You can purchase Chloroquine from our online store since we provide producer prices.

Indications for use

According to the instruction, Chloroquine can be used for the treatment of the following virus diseases:

  • Varicella-Zoster virus, which leads to shingles and chickenpox (if it doesn’t respond to Acyclovir);
  • herpes simplex virus, including in the event of ineffectiveness of its therapy with Acyclovir and other medication, as well as with long-term and unsuccessful therapy (more than 5 days). It is prescribed for exacerbations of herpes infection;
  • Herpesvirus 4 (also known as Epstein-Barr virus);
  • Cytomegalovirus, which affects eyes, lungs and digestive tract);
  • OIs in people suffering from primary and secondary immunodeficiency.
  • hepatitis A and B;

Chloroquine is very efficient in the therapy of opportunistic infections in HIV/AIDS patients.

Contraindications

The main contraindications for the use of Chloroquine are as follows:

  • increased sensitivity to the components of the medication;
  • lactation;
  • chronic kidney failure;
  • patients under 3 and over 65 years old.
  • gestation.

The drug can be prescribed on a case-by-case basis to patients aged over 65 under a doctor’s supervision.

Ways of use and dosage regimen

In adult patients, the dosage is calculated based on body weight and the type of disorder, which needs to be treated. For opportunistic infections, the starting dose is 60 mg/kg body weight 3 times a day. In the case of herpes, it is 40 mg/kg body weight 3 times a day. If you skipped a dose, you could take an increased one next time. As a rule, the therapy lasts 14-21 days.

Kids aged 3 or more must receive Chloroquine in the dose of approximately 50 mg/kg body weight 3 times a day for 3 days. Thereafter, the medicine must be used once a day in the dose of 90 mg/kg body weight once a day for a period determined by the physician.

Adverse effects

In accordance with the drug description, and given that the active component is excreted by the kidneys, the most significant adverse effect of Chloroquine is renal toxicity, which is reflected in the following implications:

  • urinary disorders;
  • swelling;
  • proteinuria;
  • nausea and vomiting;
  • interstitial nephritis;
  • tubular necrosis.

Renal toxicity frequently develops as a consequence of quick or too long administration of the medication, overdose, dehydration, and joint use of other nephrotoxic drugs. Nevertheless, it is necessary to control the level of blood creatinine and urea; if these figures are considerably above normal, hemodialysis is required. In the case of risk of developing renal toxicity, 2 liters of isotonic sodium chloride solution must be administered for preventive purposes before purchasing Chloroquine while controlling the kidney function.

Other side effects of Chloroquine

  • weakness, emotional instability, memory, and cognitive impairment;
  • head pain;
  • depressive state;
  • seizures;
  • anemia;
  • hallucinations;
  • excessive blood clotting and thrombophlebitis;
  • indigestion;
  • high body temperature;
  • irregular heartbeat;
  • allergy symptoms –hives, pruritus, and redness;
  • low blood potassium, calcium, phosphorus, and magnesium.

Due to the risk of electrolyte imbalance, the gradual introduction of the solution with electrolyte level control and the introduction of the alternative solution is advised.

Drug interaction

Simultaneous use of Acyclovir, amphotericin B, cyclosporine, and aminoglycosides can cause enhanced nephrotoxicity.

The effectiveness of Chloroquine can be affected by cyclosporin, gentamicin, streptomycin, amphotericin, tacrolimus, pentamidine, Acyclovir, and ritonavir.

Before ordering Chloroquine and beginning the therapy, you must consult your physician.

Special indications

During the treatment with Chloroquine, all patients must practice contraception.

Chloroquine can lead to sleepiness and weakness; for this reason, you must avoid driving and operating complex machinery that demands close attention.

Where can I purchase Chloroquine at a good price?

You can order Chloroquine on our webpage, as we provide the producer prices. We collaborate with lots of drug companies and supply the medicines directly.

Before buying the drug, be sure to consult a doctor, as the cost of the drug is quite high. If the price isn’t affordable for you, you can always buy generics of the drug at a lower price, whose quality is not inferior to the original.

Our company fulfills the conditions of storage and supply of the medication. On our webpage, you can buy any drugs with quality assurance. The cost of drugs is the most accessible within the region.

 

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